SKU: C167  / 
    CAS Number: 6377-18-0

    Chartreusin

    ৳43,311.74 - ৳97,489.67
    Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. Chartreusin is also a potent inhibitor of topoisomerase II.

    Chartreusin is soluble ethanol, methanol, DMF and DMSO.
    Mechanism of ActionChartreusin inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals.
    ReferencesChartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species. Leach, B.E. et al. , J.Am.Chem.Soc. 1953, 75, 4011. 

    Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of topoisomerase II. Lorico A. and Long B.H. Eur. J. Cancer 1993, 14, 1985. 

    Chartreusin, elsamicin A and related anti-cancer antibiotics. Portugal J. Curr. Med. Chem. Anticancer Agents. 2003, 3, 411.