SKU: C054  / 
    CAS Number: 33564-30-6

    Cefoxitin Sodium, USP

    Mex$1,470.00 - Mex$13,482.00

    Cefoxitin Sodium, USP is the sodium salt of Cefoxitin, a cephamycin β-lactam second-generation cephalosporin that is resistant to β-lactamases.  It has activity against several Gram-positive and Gram-negative bacteria.  Cefoxitin was discovered in 1972 and developed by Merck & Co. and Lilly from Cephamycin C.  It was synthesized in order to broaden its spectrum.  

    Cefoxitin Sodium is freely soluble in aqueous solution.  

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    Mechanism of Action Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephamycins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephamycins, Cefoxitin is resistant to β-lactamases.
    Spectrum Cefoxitin is a broad-spectrum antibiotic effective against several Gram-positive and Gram-negative bacteria. Like many cephamycins, Cefoxitin is particularly effective against anaerobic bacteria.
    Microbiology Applications Cefoxitin Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:
    • Bacteroides fragilis 1 µg/mL – 8 µg/mL
    • Bacillus cereus 8.6 µg/mL
    • For a representative list of Cefoxitin MIC values, click here.
    Molecular Formula C16H16N3NaO7S2
    Assay Dried Basis:
    927 - 970 µg/mg (based on C16H17N3O7S2);
    97.5% - 102.0% (based on C16H16N3NaO7S2)

    Georgopapadakou NH (1992)  Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents. Chemother. 37 (3):559-565