SKU: A099  / 
    CAS Number: 95233-18-4

    Atovaquone

    RM353.75 - RM1,502.38
    Atovaquone is a hydroxynaphthoquinone antimicrobial compound with antipneumocystic and anti-parasitic properties.
    Mechanism of ActionAtovaquone inhibits cytochrome bc1 of the electron transport system leading to failure of mitochondrial function.
    SpectrumAtovaquone is active against Plasmodium spp, Pneumocystis carinii, and Toxoplasma gondii in vivo and in vitro.
    Impurity ProfileRelated Substances (HPLC):
    RRT - 0.63: Not more than 0.5%
    RRT - 0.89: Not more than 0.3%
    RRT - 1.8: Not more than 0.5%
    Related Compound A: Not more than 1.0%
    Any other impurity: Not more than 0.2%
    Total other impurities: Not more than 1.0%
    Total impurities: Not more than 1.5%
    Molecular FormulaC22H19ClO3
    SolubilityFreely soluble in N-methyl-2-pyrolidone and in tetrahydrofuran; slightly soluble in ethyl acetate; insoluble in water
    Impurity ProfileRelated Substances (HPLC):
    RRT - 0.63: Not more than 0.5%
    RRT - 0.89: Not more than 0.3%
    RRT - 1.8: Not more than 0.5%
    Related Compound A: Not more than 1.0%
    Any other impurity: Not more than 0.2%
    Total other impurities: Not more than 1.0%
    Total impurities: Not more than 1.5%
    Residual SolventsMethanol: Not more than 2000ppm
    Chloroform: Not more than 60ppm
    Dichloromethane: Not more than 600ppm
    Acetonitrile: Not more than 410ppm
    ReferencesLooareesuwan, Sornchai, Jeffrey D. Chulay, Craig J. Canfield, and David B. Hutchinson. "MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE): A REVIEW OF ITS CLINICAL DEVELOPMENT FOR TREATMENT OF MALARIA." The American Society of Tropical Medicine and Hygiene 60.4 (1999): 533-41.

    Nixon, G. L., D. M. Moss, A. E. Shone, D. G. Lalloo, N. Fisher, P. M. O'neill, S. A. Ward, and G. A. Biagini. "Antimalarial Pharmacology and Therapeutics of Atovaquone." Journal of Antimicrobial Chemotherapy68.5 (2013): 977-85.