Amphotericin B, Solubilized, Lyophilized is an optimized version of Amphotericin B. It is formulated with sodium deoxycholate to maximize the water solubility as lipotrophic molecules such as deoxycholate improve its solubility. Although Amphotericin B has an amphiphilic region, its water solubility is inherently low. The product has also been lyophilized to remove moisture, enhance stability and improve shelf life.
Amphotericin B is a a polyene macrolide aminoglycoside broad-spectrum antimycotic. This bioactive natural product was originally isolated from soil collected from the Orinoco River (Venezuela) in 1955 and identified as Streptomyces nodosus by Squibb Institute for Medical Research. It is used to control contamination from fungi, viruses and protozoa and a common media selective agent to inhibit the growth of background fungi. It also has immunomodulatory properties.
Amphotericin B, Solubilized, Lyophilized is soluble in water.
The Centers for Disease Control (CDC) Standard Operating Procedure (SOP) DSR-052-04 includes the addition of Amphotericin B to viral transport media for SARS-CoV2 samples.
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