• Zaragozic acid A packaged and labeled in glass vial.

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SKU: Z006

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Description
Zaragozic acid A is the major metabolite of a class of unusual bicyclic tricarboxylic acids, produced by a number of fungi in the genera Curvularia, Exserohilum, Setosphaeria and others, discovered at Merck and Glaxo in the early 1990s. Zaragozic acid A is presented as the free acid rather than the tri-sodium salt to avoid stability problems associated with hydrolysis of the salt.

Zaragozic acid A is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    142561-96-4

    Molecular Formula

    C35H46O14

    Molecular Weight

    690.7

    Mechanism of Action

    Zaragozic acid A is an inhibitor of squalene synthase, an enzyme involved in sterol biosynthesis.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White to light tan solid

References

    References

    The zaragozic acids. A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Bergstrom J.D. et al. Proc. Nat. Acad. Sci. 1993, 90, 80.

    Distribution of zaragozic acids (squalestatins) among filamentous ascomycetes. Bills G.F. Mycol. Res. 1994, 98, 733-739.

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