• Tylosin B, EvoPure packaged and labeled.

click on thumbnail to zoom
SKU: T057

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Tylosin B, EvoPure® is a highly purified form of tylosin B or desmycosin. Tylosin B is a metabolite of tylosin A and forms in acidic media. 

Tylosin is a macrolide antibiotic that was originally isolated from Streptomyces fradiae by the Lilly Research Laboratories in 1961 from a soil sample collected in Thailand. Tylosin is a mixture of four macrolide antibiotics, the main component of the mixture (> 80%) is tylosin A; tylosin B (desmycosin), tylosin C (macrocin), and tylosin D (relomycin) may also be present.  Tylosin has broad spectrum bacteriostatic activity against gram-positive bacteria and mycoplasma, but much less activity against most gram-negative bacteria and fungi.

Tylosin, like other Macrolide antibiotics, is a bacteriostatic compound that reversibly bind to the 23S rRNA in the 50S (L27 protein) ribosome subunit and inhibit mRNA-directed protein synthesis.

Tylosin has been used to study protein synthesis, abscess prevention in cattle, and Mycoplasma infections.

For more Tylosin products click here.

    CAS Number

    11032-98-7

    Molecular Formula

    C39H65NO14

    Molecular Weight

    771.93

    Mechanism of Action

    Tylosin, like other Macrolide antibiotics, is a bacteriostatic compound that reversibly bind to the 23S rRNA in the 50S (L27 protein) ribosome subunit and inhibit mRNA-directed protein synthesis. Tylosin B was shown not to inhibit peptidyl transferase (Poulsen et al., 2000).

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1010

    Spectrum

    Tylosin shows activity primarily against gram-positive bacteria and species of the Mycoplasma genus

Applications

    Application

    Tylosin B, EvoPure® can be used as a reference standard and to study the individual effects of tylosin B.

Specifications

    Form

    Powder

    pH

    7.5-8.5

    Melting Point

    85-95°C

References

    References

    Loke, M. L., and F. Ingerslev. "Stability of Tylosin A in Manure Containing Test Systems Determined by High Performance Liquid Chromatography." Chemosphere 40.7 (2000): n. pag. Nih.gov. Web. 27 Dec. 2013.

    Thompson, T. S., S. F. Pernal, and D. K. Noot. "Degradation of Incurred Tylosin to Desmycosin--implications for Residue Analysis of Honey." Analytica Chimica 586 (2007): 304-11. Nih.gov. Web. 27 Dec. 2013.

Other Items In This Category