• Thielavin B packaged and labeled in glass vial.

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SKU: T089

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Description
Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis.

Thielavin B is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    71950-67-9

    Molecular Formula

    C31H34O10

    Molecular Weight

    566.6

    Mechanism of Action

    Thielavins inhibit glucose-6-phosphatase.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Powder

References

    References

    Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities. Sakemi S. et al. J. Antibiot. 2002, 55, 941.

    The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi. Kitahara N. et al. J. Antibiot. 1983, 36, 599.

    Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. Togashi K. et al. Biosci. Biotechnol. Biochem. 2001, 65, 651.

    Screening systems for detecting inhibitors of cell wall transglycosylation inhibitors in Enterococcus. Mani N., et al. J. Antibiot. 1998, 51, 471.

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