• Thielavin A packaged and labeled in glass vial.

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SKU: T088

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Description
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.

Thielavin A is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    71950-66-8

    Molecular Formula

    C29H30O10

    Molecular Weight

    538.5

    Mechanism of Action

    Thielavin A inhibits glucose-6-phosphatase.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Powder

References

    References

    Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities. Sakemi S. et al. J. Antibiot. 2002, 55, 941.

    Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. Togashi K. et al. Biosci. Biotechnol. Biochem. 2001, 65, 651.

    Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus. Mani N. et al. J. Antibiot. 1998, 51, 471.

    The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi. Kitahara N. et al. J. Antibiot. 1983, 36, 599.

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