• Puromycin packaged and labeled in glass vial.

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SKU: P097

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Description
Puromycin is a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypanosomal agent with antibiotic activity. Puromycin is used in cell biology to select mammalian cell lines that have been transformed by vectors that express puromycin-N-acetyl-transferase.

Puromycin is soluble in ethanol, methanol, DMF and DMSO and has moderate solubility in water.

    CAS Number

    53-79-2

    Molecular Formula

    C22H29N7O5

    Molecular Weight

    471.5

    Mechanism of Action

    Puromycin is non-selective, inhibiting RNA by blocking ribosomal translation.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White powder

References

    References

    Achromycin, the structure of the antibiotic puromycin. Waller C.W.J., Am. Chem. Soc. 1953, 75, 2025.

    Biosynthesis of puromycin by Streptomyces alboniger. Characterization of puromycin N-acetyltransferase. Vara J. et al. , Biochemistry 1985, 24, 8074.

    Unexpected cytokinetic effects induced by puromycin include a G2- arrest, a metaphase-mitotic-arrest, and apoptosis. Davidoff A.N. & Mendelow B.V., Leuk. Res. 1992, 16, 1077.

    Puromycin inhibition of protein synthesis: incorporation of puromycin into peptide chains. Nathans D., Proc. Nat. Acad. Sci. 1964, 51, 585.

    Effect of puromycin analogues and other agents on peptidyl-puromycin synthesis on polyribosomes. Petska S. et al. , Antimicrobial Agents Chemother. 1973, 4, 37.

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