• Milbemycin oxime

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SKU: M015

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Description
Milbemycin oxime is a broad spectrum antiparasitic compound with activity against insects, mites, and worms. Milbemycin oxime is composed of a mixture of two related compounds - milemycin A3 and A4.
 

    CAS Number

    129496-10-2

    Molecular Formula

    Milbemycin A3 - C31H43NO7
    Milbemycin A4 - C32H45NO7

    Molecular Weight

    541.7 (A3), 555.7 (A4)

    Mechanism of Action

    Milbemycin oxime inhibits fungal growth by inhibiting ATP-binding cassette (ABC) transporters.

    Storage Conditions

    ≤30°C

    Spectrum

    Milbemycin oxime is active against fungal pathogens Candida albicans, Candida glabrata, and parasitic worms, insects, and mites.

Specifications

    Appearance

    White or light yellow powder

    Source

    Semi-synthetic

    Impurity Profile

    Impurity G: Not more than 2.0%
    Impurity E: Not more than 0.7%
    Impurity H: Not more than 0.5%
    Impurity I: Not more than 0.5%
    Any other impurity: Not more than 0.2%
    Total impurities: Not more than 3.5%

    Assay

    (A3 + A4): 95.0 - 102.0%
    A3 Ratio: Not more than 0.20
    A4 Ratio: Not less than 0.80

    Residual Solvents

    Ethanol: Not more than 5000 ppm
    Acetone: Not more than 5000 ppm
    n-Heptane: Not more than 5000 ppm
    Methanol: Not more than 3000 ppm
    4-Dioxane: Not more than 380 ppm
    Methylene chloride: Not more than 600 ppm
    Chloroform: Not more than 60 ppm

References

    References

    Silva, Luis Vale. "Milbemycins: More than Efflux Inhibitors for Fungal Pathogens." American Society for Microbiology 57 (n.d.): 873-886. Web. 27 Jan. 2016.

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