SKU: M074

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Description
Magainin II is an antimicrobial peptide originally isolated from Xenopus laevis, with excellent antibiotic activity across a broad-spectrum. It has also demonstrated antifungal activity in vitro and anticancer activity in vitro and in a mouse model.

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    CAS Number

    108433-95-0

    Molecular Formula

    C114H180N30O29S

    Molecular Weight

    2466.9

    Mechanism of Action

    Magainin II is believed to form pores in the target bacterial membrane, causing lysis and death.

References

    References

    Imura, Y., Choda, N., & Matsuzaki, K. (2008). Magainin 2 in Action: Distinct Modes of Membrane Permeabilization in Living Bacterial and Mammalian Cells. Biophysical Journal, 95(12), 5757-5765. doi:10.1529/biophysj.108.133488

    Lehmann, J., Retz, M., Sidhu, S. S., Suttmann, H., Sell, M., Paulsen, F., . . . Stöckle, M. (2006). Antitumor Activity of the Antimicrobial Peptide Magainin II against Bladder Cancer Cell Lines. European Urology, 50(1), 141-147. doi:10.1016/j.eururo.2005.12.043

    Zasloff, M. (1988). Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Journal of Ethnopharmacology, 23(2-3), 360. doi:10.1016/0378-8741(88)90095-5

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