SKU: M073

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Description
Magainin I is a 23 residue long antimicrobial peptide originally discovered in the skin of Xenopus laevis. It has shown broad-spectrum antibiotic activity, particularly of E. coli, and antifungal activity.

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    CAS Number

    108433-99-4

    Molecular Formula

    C112H177N29O28S

    Molecular Weight

    2409.85

    Mechanism of Action

    Magainin I is believed to form pores in the target bacterial membrane, causing lysis and death.

References

    References

    Imura, Y., Choda, N., & Matsuzaki, K. (2008). Magainin 2 in Action: Distinct Modes of Membrane Permeabilization in Living Bacterial and Mammalian Cells. Biophysical Journal, 95(12), 5757-5765.
    doi:10.1529/biophysj.108.133488

    Zasloff, M. (1988). Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Journal of Ethnopharmacology, 23(2-3), 360. doi:10.1016/0378-8741(88)90095-5

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