Lamivudine

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Lamivudine

SKU: L019

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Description

Lamivudine (3TC) is a cytidine analog and antiretroviral medication commonly used to treat HIV and hepatitis B infections.

CAS Number

134678-17-4

Molecular Formula

C₈H₁₁N₃O₃S

Molecular Weight

229.26

Mechanism of Action

Lamivudine inhibits HIV reverse transcriptase and terminates DNA synthesis by competing for incorporation into viral DNA.

Storage Conditions

≤30°C

Spectrum

Lamivudine targets retroviruses hepatitis B virus (HBV) and human immunodeficiency virus (HIV).

Applications

Specifications

Impurity Profile

Lamivudine Enantiomer: Not more than 0.3%
Impurity 1 (0.4 Ret. Time): Not more than 0.3%
Impurity 2 (0.9 Ret. Time): Not more than 0.2%
Salicylic Acid: Not more than 0.1%
Individual impurity: Not more than 0.1%
Total impurities: Not more than 0.6%

Water Content (Karl Fisher)

Not more than 0.2%

Absorbance

(440nm): Not more than 0.0015

Melting Point

175 - 179°C

Optical Rotation

-135.0 - -145.0°

Assay

98.0 - 102.0%

Loss on Drying

Not more than 0.5%

Sulfated Ash

Not more than 0.1%

Heavy Metals

Not more than 20ppm

Residual Solvents

Alcohol: Not more than 0.2%
Isopropyl Acetate: Not more than 0.2%
Methanol: Not more than 0.1%
Triethylamine: Not more than 0.1%
Total Residual Solvents: Not more than 0.3%

Technical Data

References

Balzarini, Jan, Lieve Naesens, and Erik De Clercq. "New Antivirals — Mechanism of Action and Resistance Development." Current Opinion in Microbiology 1.5 (1998): 535-46. Web.