• Lamivudine

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SKU: L019

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Description
Lamivudine (3TC) is a cytidine analog and antiretroviral medication commonly used to treat HIV and hepatitis B infections.

    CAS Number

    134678-17-4

    Molecular Formula

    C8H11N3O3S

    Molecular Weight

    229.26

    Mechanism of Action

    Lamivudine inhibits HIV reverse transcriptase and terminates DNA synthesis by competing for incorporation into viral DNA.

    Storage Conditions

    ≤30°C

    Spectrum

    Lamivudine targets retroviruses hepatitis B virus (HBV) and human immunodeficiency virus (HIV).

Specifications

    Impurity Profile

    Lamivudine Enantiomer: Not more than 0.3%
    Impurity 1 (0.4 Ret. Time): Not more than 0.3%
    Impurity 2 (0.9 Ret. Time): Not more than 0.2%
    Salicylic Acid: Not more than 0.1%
    Individual impurity: Not more than 0.1%
    Total impurities: Not more than 0.6%

    Water Content (Karl Fisher)

    Not more than 0.2%

    Absorbance

    (440nm): Not more than 0.0015

    Melting Point

    175 - 179°C

    Optical Rotation

    -135.0 - -145.0°

    Assay

    98.0 - 102.0%

    Loss on Drying

    Not more than 0.5%

    Sulfated Ash

    Not more than 0.1%

    Heavy Metals

    Not more than 20ppm

    Residual Solvents

    Alcohol: Not more than 0.2%
    Isopropyl Acetate: Not more than 0.2%
    Methanol: Not more than 0.1%
    Triethylamine: Not more than 0.1%
    Total Residual Solvents: Not more than 0.3%

References

    References

    Balzarini, Jan, Lieve Naesens, and Erik De Clercq. "New Antivirals — Mechanism of Action and Resistance Development." Current Opinion in Microbiology 1.5 (1998): 535-46. Web.

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