• Kigamicin C packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: K023

  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria.

Kigamicin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number


    Molecular Formula


    Molecular Weight


    Mechanism of Action

    The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients.

    Storage Conditions




    Pale yellow powder



    Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation. Lu J. et al. Cancer Sci. 2004, 95, 547.

    Kigamicins, novel antitumor antibiotics. II. Structure determination. Kunimoto S. et al. J. Antibiot. 2003, 56, 1012.

    Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities. Kunimoto S. et al. J. Antibiot. 2003, 56, 1004.

Other Items In This Category