• Filipin packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: F020

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.

Filipin complex is soluble in ethanol, methanol, DMF or DMSO.  

    CAS Number

    11078-21-0

    Molecular Formula

    C35H58O11 (for Flipin III)

    Molecular Weight

    654.8

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow solid

References

    References

    Filipin, an antifungal antibiotic: Isolation and properties. Whitfield G.B. et al. J. Am. Chem. Soc. 1955, 77, 4799.

    Separation of polyene antifungal antibiotics by high speed liquid chromatography. Mechlinski W. & Schaffner C.P. J. Chromatogr. 1974, 99, 619.

    Inhibition of fungi by filipin and its antagonism by sterols. Gottlieb D. et al. Phytopathology 1960, 50, 594.

Other Items In This Category