• Doxycycline packaged and labeled in glass vial.

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SKU: D064

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Doxycycline is a semi-synthetic tetracycline prepared by hydrogenolysis of oxytetracycline to remove the 6-hydroxy group. Although the synthesis was reported in 1958, it was not released for use until 1967. Doxycycline, together with minocycline, is regarded as a "third generation" tetracycline largely replacing the analogues and pro-drugs produced in the early 1960s for mainstream antibiotic applications. Like all tetracyclines, doxycycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Doxycycline has been extensively cited in the literature with over 10,000 references.

Doxycycline is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number


    Molecular Formula

    C22H24N2O8 · H2O

    Molecular Weight


    Mechanism of Action

    Doxycycline blocks protein synthesis by binding to the 30S and 50S ribosomal subunits.



    Yellow to orange solid



    Hydrogenolysis studies in the tetracycline series - 6-Deoxytetracyclines. Stephens C.R. et al. J. Am. Chem. Soc. 1958, 80, 5324.

    Comparison of in vitro activity and clinical pharmacology of doxycycline with other tetracyclines. Rosenblatt J.E. et al. Antimicrob. Agents Chemother. 1966, 6, 134.

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