• Chrysomycin B, EvoPure� packaged and labeled in glass vial.

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SKU: C154

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Description
Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II.

Chrysomycin B is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.

    CAS Number

    83852-56-6

    Molecular Formula

    C27H28O9

    Molecular Weight

    496.5

    Mechanism of Action

    The mechanism of action of chrysomycins is not fully understood; however, recent research suggests chrysomycins may act as photoactivated cross-linkers of DNA to histones.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow crystals

References

    References

    Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of human topoisomerase II. Lorico A. et al. , Eur. J. Cancer. 1993, 29A, 1985. 

    Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000. 

    Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. et al. Cancer Res. 2000, 60, 3921.

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