• Chloramphenicol succinate sodium packaged and labeled in glass vial.

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SKU: C170

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Description
Chloramphenicol succinate sodium is the salt prepared from chloramphenicol succinate using the free carboxylic acid of the succinate which ionises and readily forms in weak sodium hydroxide solutions. The sodium salt is the preferred formulation for pharmaceutical applications, providing a more readily soluble product. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.

Chloramphenicol succinate sodium is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    982-57-0

    Molecular Formula

    C15H15Cl2N2O8Na

    Molecular Weight

    445.2

    Mechanism of Action

    After entering a bacterial cell, chloramphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to chloramphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Ambekar C.S. et al. Toxicology in Vitro 2004, 18, 441.

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