• Chartreusin packaged and labeled in glass vial.

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SKU: C167

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Description
Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. Chartreusin is also a potent inhibitor of topoisomerase II.

Chartreusin is soluble ethanol, methanol, DMF and DMSO.

    CAS Number

    6377-18-0

    Molecular Formula

    C32H32O14

    Molecular Weight

    640.6

    Mechanism of Action

    Chartreusin inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow solid

References

    References

    Chartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species. Leach, B.E. et al. , J.Am.Chem.Soc. 1953, 75, 4011. 

    Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of topoisomerase II. Lorico A. and Long B.H. Eur. J. Cancer 1993, 14, 1985. 

    Chartreusin, elsamicin A and related anti-cancer antibiotics. Portugal J. Curr. Med. Chem. Anticancer Agents. 2003, 3, 411.

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