• Cefotetan disodium packaged and labeled.

click on thumbnail to zoom
SKU: C117

  Click 'Bulk Order' for 10 or more
Price: make selection(s)

Cefotetan disodium is a cephamycin antibiotic grouped with the second generation cephalosporins. TOKU-E offers two forms of cefotetan: cefotetan (C012) and cefotetan disodium (C117). Ceftotetan is sparingly soluble in water (0.51 mg/mL) and cefotetan disodium is slightly more soluble at 1 mg/mL.

    CAS Number


    Molecular Formula


    Molecular Weight


    Mechanism of Action

    Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactam antibiotics is commonly due to cells containing plasmid encoded β-lactamases, however, many cephamycins are unaffected by this mechanism.

    Storage Conditions


    Tariff Code



    Cefotetan is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria. Like many cephamycins, cefotetan is very effective against anaerobic bacteria such as Bacteroides and Clostridium species.


    Microbiology Applications

    Cefotetan is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against aerobic and anaerobic gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Bacteroides fragilis 2 µg/mL – 512 µg/mL
    • Clostridium difficile 8 µg/mL - 32 µg/mL
    • For additional cefotetan MIC values, click here.





    White or Light Yellow Powder


    (HPLC, As Is): ≥95.0%

Technical Data

HPLC Chromatogram Showing Ultra High Purity of Cefotetan Disodium

cefotetan HPLC



    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

Other Items In This Category