• Cefmetazole, free acid packaged and labeled.

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SKU: C122

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Description

Cefmetazole is a broad spectrum second generation cephalosporin antibiotic. TOKU-E offers two forms of cefmetazole: cefmetazole, free acid (C122), and cefmetazole sodium (C052). Cefmetazole is freely soluble in water 92 mg/mL.

    CAS Number

    56796-20-4

    Molecular Formula

    C15H17N7O5S3

    Molecular Weight

    471.53

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefmetazole is broad spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria. Cefmetazole is more potent against many Gram-negative enteric flora and pathogens than other first generation cephalosporins.

Applications

    Microbiology Applications

    Cefmetazole is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Bacteroides fragilis 4 μg/mL - 32 μg/mL
    • Propionibacterium acnes 0.06 μg/mL - 0.25 μg/mL

    For a complete list of cefmetazole MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Impurity Profile

    Individual impurity: Not more than 1.0%
    Total impurities: Not more than 2.0

    Water Content (Karl Fisher)

    Not more than 1.0%

    pH

    2 - 4

    Melting Point

    145°C - 155°C

    Optical Rotation

    +80° - +88°

    Assay

    Not less than 97.0%

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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