SKU: C281  / 
    CAS Number: 62893-19-0

    Cefoperazone Free Acid

    $59.00 - $134.00

    Cefoperazone Free Acid is a semi-synthetic, broad-spectrum third-generation cephalosporin. Patented in 1974, it was marketed by Pfizer under the trade name Cefobid. The compound has activity against Pseudomonas. It has a tetrazolyl moiety that confers β-lactamase resistance. Cefoperazone may be used as an analytical standard for the determination of cefoperazone in raw bovine milk.

    Cefoperazone Free Acid is slightly soluble in DMSO and Methanol.

    Mechanism of Action Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. 

    Spectrum Cefoperazone Free Acid has broad-spectrum activity, including activity against Pseudomonas. It is effective against a wide variety of Gram-positive and Gram-negative bacteria.
    Microbiology Applications Cefoperazone is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.

    Representative MIC values include:

    Haemophilus influenzae: 0.12 - 0.25 µg/ml
    Staphylococcus aereus: 0.125 - 32 µg/ml
    Streptococcus pneumoniae:≤ 0.007 - 1 µg/ml

    For a representative list of Cefoperazone MIC values, click here

    Molecular Formula C25H27N9O8S2

    Crosby MA and Gump DW (1982) Activity of Cefoperazone and two beta-lactamase inhibitors, sulbactam and clavulanic acid, against Bacteroides spp. correlated with beta-lactamase production. Antimicrob. Agents Chemother. 22(3):398-405 PMID 6291451

    Matsubara N, Minami S, Muraoka T, Saikawa I and Mitsuhashi S (1979) In vitro antibacterial activity of Cefoperazone (T-1551), a new semisynthetic cephalosporin. Antimicrob. Agents Chemother. 16(6):731-735  PMID 316988