• Bischloroanthrabenzoxocinone packaged and labeled in glass vial.

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SKU: B050

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Description
Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 µg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. FASII is essential to bacterial cell viability and is a promising target for the development of novel antibiotics.

Bischloroanthrabenzoxocinone is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    866022-28-8

    Molecular Formula

    C28H24O7Cl2

    Molecular Weight

    542.1

    Mechanism of Action

    BABX has been shown to inhibit agonist binding to Liver X receptors (LXR). These receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Light orange residue

References

    References

    Determination of selectivity and efficacy of fatty acid synthesis inhibitors. Kodali S. et al. , J. Biol. Chem. 2005, 280, 1669. 

    Anthrabenzoxocinones from Streptomyces sp. as Liver X receptor ligands and antibacterial agents. Herath K. B. et al. , J. Nat. Prod. 2005, 68, 1437.

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