• Atovaquone

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SKU: A099

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Description
Atovaquone is a hydroxynaphthoquinone antimicrobial compound with antipneumocystic and anti-parasitic properties.

    CAS Number

    95233-18-4

    Molecular Formula

    C22H19ClO3

    Molecular Weight

    366.837

    Mechanism of Action

    Atovaquone inhibits cytochrome bc1 of the electron transport system leading to failure of mitochondrial function.

    Storage Conditions

    -20┬░C

    Spectrum

    Atovaquone is active against Plasmodium spp, Pneumocystis carinii, and Toxoplasma gondii in vivo and in vitro.

Specifications

    Form

    Powder

    Appearance

    Yellow powder

    Source

    Synthetic

    Impurity Profile

    Related Substances (HPLC):
    RRT - 0.63: Not more than 0.5%
    RRT - 0.89: Not more than 0.3%
    RRT - 1.8: Not more than 0.5%
    Related Compound A: Not more than 1.0%
    Any other impurity: Not more than 0.2%
    Total other impurities: Not more than 1.0%
    Total impurities: Not more than 1.5%

    Water Content (Karl Fischer)

    Not more than 1.0%

    Assay

    (HPLC): 97.5% - 101.5%

    Residue On Ignition

    Not more than 0.1%

    Heavy Metals

    Not more than 10ppm

    Residual Solvents

    Methanol: Not more than 2000ppm
    Chloroform: Not more than 60ppm
    Dichloromethane: Not more than 600ppm
    Acetonitrile: Not more than 410ppm

References

    References

    Looareesuwan, Sornchai, Jeffrey D. Chulay, Craig J. Canfield, and David B. Hutchinson. "MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE): A REVIEW OF ITS CLINICAL DEVELOPMENT FOR TREATMENT OF MALARIA." The American Society of Tropical Medicine and Hygiene 60.4 (1999): 533-41.

    Nixon, G. L., D. M. Moss, A. E. Shone, D. G. Lalloo, N. Fisher, P. M. O'neill, S. A. Ward, and G. A. Biagini. "Antimalarial Pharmacology and Therapeutics of Atovaquone." Journal of Antimicrobial Chemotherapy68.5 (2013): 977-85.

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