• Antimycin packaged and labeled in glass vial.

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SKU: A129

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Description
Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.

Antimycin A is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    1397-94-0

    Molecular Formula

    C28H40N2O9 (for A1)

    Molecular Weight

    548.6 (for A1)

    Mechanism of Action

    Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    The isolation and properties of antimycin A. Bryant R. & Dunshee B.R. et al. J. Am. Chem. Soc. 1949, 71, 2436.

    Inhibition of electron transport by antimycin A, alkyl hydroxy naphthoquinones and metal coordination compounds. Tappel A.L. Biochem. Pharmacol. 1960, 3, 289.

    Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production. Yan Y. et al. Org. Lett. 2012, 14, 4142.

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