SKU: T053  / 
    CAS Number: 23313-80-6

    4-Epitetracycline HCl, EvoPure®


    4-Epitetracycline HCl, EvoPure® is a highly purified hydrochloride salt form of 4-Epitetracycline.  Under acidic conditions, Tetracycline undergoes an epimerization at the fourth carbon, producing a mixture of Tetracycline and 4-Epitetracycline.  This EvoPure product is soluble in water.

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    Application4-Epitetracycline HCl, EvoPure® can be used as an analytical standard.
    Mechanism of ActionTetracycline inhibits the growth of Gram-positive and Gram-negative bacteria by disrupting codon-anticodon interactions at the ribosome, thus blocking protein synthesis. Specifically, Tetracycline binds to the 30S ribosomal subunit and blocks the attachment of charged aminoacyl-tRNA to the A site on the ribosome, preventing peptide elongation.
    SpectrumEffective against Gram-positive and Gram-negative bacteria, and Mycoplasma.
    Molecular FormulaC22H24N2O8 · xHCl (lot specific)
    Molecular Weight444.43 g/mol (Free base. Actual molecular weight shown on lot specific certificate of analysis).

    Mazur X, Eppenberger HM, Bailey JE and FUssenegger M (2000)  A novel autoregulated proliferation-controlled production process using recombinant CHO cells.   Biotechnol and Bioeng.  65(2):144-150

    Fernandez AA, Noceda VT, Carrera ES (1969)  Simultaneous separation and quantitative determination of tetracycline, anhydrotetracycline, 4-epitetracycline, and 4-epi-anhydrotetracycline in degraded tetracyclines by thin-layer chromatography. J. Pharm. Sci. 58(4):443-446