SKU: S009  / 
    CAS Number: 18883-66-4



    Streptozocin is an anti-tumor agent commonly used in metastatic cancer of pancreatic islet cells. Streptozocin is freely soluble in aqueous solution (>100 mg/mL).

    Mechanism of Action Streptozocin acts as an alkylating agent which damages DNA by adding methyl and other alkyl groups which interfere with normal base pairing.
    Impurity Profile α-isomer: ≥75.0%
    Residue on Ignition: ≤0.1%
    Heavy Metals: ≤20ppm
    Eukaryotic Cell Culture Applications Streptozocin is frequently used to induce diabetes and insulitis for diabetes research in mamalian models.

    Streptozocin (TOKU-E) was used in a study by Xufeng et al. : Effects of Radix linderae extracts on a mouse model of diabetic bladder dysfunction in later decompensated phase
    Cancer Applications Streptozocin has shown to decrease tumor size and relevant tumor-induced symptoms including hypoglycemia.
    Molecular Formula C8H15N3O7
    References Murray-Lyon IM et al (1968). Treatment of multiple-hormone-producing malignant islet-cell tumour with streptozotocin. Lancet 2 (7574): 895–898

    Broder LE and Carter SK (1973)  Pancreatic islet cell carcinoma. II. Results of therapy with Streptozotocin in 52 patients. Ann. Intern. Med 179:108–118

    Moertel CG, Hanley JA and Johnson LA (1980)  Streptozocin alone compared with streptozocin plus fluorouracil in the treatment of advanced islet-cell carcinoma . N Eng. J Med 303:1189–1194