SKU: S132  / 
    CAS Number: 121009-77-6

    Simvastatin Acid

    $207.00 - $725.00

    Simvastatin acid is the active β-hydroxy acid metabolite of simvastatin formed in vivo. Simvastatin acid is a potent inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, an essential enzyme involved in the in vivo synthesis of cholesterol. Simvastatin acid stimulates bone formation by increasing expression of BMP-​2 (bone morphogenic protein-2) in osteoblasts.

    Molecular Formula  C25H40O6

    Hoffman WF et al (1986)  3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. J. Med.Chem. 29:849

    Yoshinari M et al (2007)  Controlled release of simvastatin acid using cyclodextrin inclusion system. Dental Materials J. 26:451