Antimicrobials

Epoxysuberosin, (+)-

(+)-Epoxysuberosin is a coumarin isolated from Hesperethusa crenulata by Nayar and Bhan from Regional ResearchLaboratory, India, in 1972. More recently, Smith and Bissember at the University of Tasmania, Australia, isolatedepoxysuberosin from the native...

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FR 179642

FR 179642 is a member of the echinocandin antifungal family patented in 1991 by Ueda and colleagues at Fujisawa, nowAstellas Pharma. FR 179642 is formed by the selective hydrolysis of FR 901379 using a cyclic lipopeptide acylase found in<0.1% of soil...

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FR 901379

FR 901379 is a pneumocandin belonging to the echinocandin class of cyclic lipopeptides produced by Coleophoma empetri F11899, discovered as antifungals and patented in 1991 by Ueda and colleagues. FR 901379 inhibits the synthesis of 1,3-β-D glucan...

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Galbinic Acid

Galbinic Acid (α-acetylsalazinic acid) is a depsidone isolated from the lichen, Usnea undulata. The structure of galbinic acid was elucidated by Elix, Australian National University in 1975. Galbinic Acid is moderately active against Gram-positive...

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Leoidin

Leoidin is a metabolite of the lichen, Lecanora gangleoides, first published in 1986 and recently reported as an inhibitor ofprotein synthesis in Pseudomonas aeruginosa. Leoidin is bacteriostatic, targeting PheRS. Leoidin is a weak inhibitor of human...

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Methyl Betulinate

Methyl Betulinate is the methyl ester of Betulinic Acid, a pentacyclic lupane terpene isolated as a constituent of various tree species, including birch. In Australia, Methyl Betulinate was isolated from Akania bidwillii (syn. Akania lucens) by Ritchie...

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Mer-NF5003E

Mer-NF5003E is a sesquiterpenoid mycotoxin isolated from Stachybotrys strains, first published in 1994 as an avianmyeloblastosis virus (AMV) protease inhibitor. Mer-NF5003E is inactive against HIV due to host cell toxicity. An analogue, MerNF5003B has...

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Mer-NF5003F

Mer-NF5003F is a sesquiterpenoid mycotoxin isolated from Stachybotrys strains, first published in 1994 as an avianmyeloblastosis virus (AMV) protease inhibitor. Mer-NF5003F is inactive against HIV due to host cell toxicity. An analog, MerNF5003B has been...

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Manumycin A

Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has...

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Novobiocic Acid

Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial...

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Polygodial

Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder atCSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and...

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Strychnospermine

Strychnospermine is an alkaloid isolated by Ritchie et al. at the University of Sydney, Australia from the Australian native strychnine tree, Strychnos psilosperma, in 1950. There are no published reports of the biological activity of Strychnospermine. ...

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