Immunosuppressants

Isocyclosporin A

Isocyclosporin A is a rearranged degradation product formed by acid treatment of Cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying Cyclosporin A. The pharmacology...

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L-Penicillamine

L-Penicillamine is a metabolite of penicillin that acts as a copper chelating agent. TOKU-E offers both D-penicillamine (P107) and L-penicillamine (P112). While they are enantiomers of each other with equal copper chelating ability, L-penicillamine has a...

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Lactoferricin B, fragment 4-14 trifluoroacetate salt

Lactoferricin B is a broad-spectrum antimicrobial peptide (AMP) that is generated by the enzymatic digestion of lactoferrin. Lactoferricin B is derived from bovine lactoferrin. Lactoferricin B has activity against gram-positive and gram-negative...

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LL Z1640-2

LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation...

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LL-37 (human) trifluoroacetate salt

LL-37 is a naturally-occuring antimicrobial peptide that is part of the innate host immune system. It is associated with the epidermis and protects the host from bacterial infection. LL-37 has also demonstrated a range of other bioactivity including...

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Luteoreticulin

Luteoreticulin is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers SNF4435C and SNF4435D. Metabolites within this class are potent antitumor agents with pronounced immunosuppressive activity, and more...

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Matrine

Matrine is an alkaloid extracted from the Chinese Sophora herb plants. As a natural product it has a relatively low toxicity. Matrine has demonstrated antiviral and anti-inflammatory bioactivity. Additionally, it has been shown to induce apoptosis in...

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Melittin

Melittin is the principal toxic component of honey bee venom from Apis mellifera, making up 50% of its dry weight. It is a 26 residue long antimicrobial peptide has an α-helical conformation, and associates strongly with membranes. It has demonstrated...

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Methotrexate

Methotrexate is a selective agent for dihydrofolate reductase (DHFR)- transfected cells, and a nucleic acid synthesis inhibitor in protein expression systems, thus can be used as an ancillary material in upstream biomanufacturing applications.  It...

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Methotrexate Sodium

Methotrexate Sodium is a selective agent for dihydrofolate reductase (DHFR)- transfected cells and a nucleic acid synthesis inhibitor in protein expression systems. It is commonly used as an ancillary material in upstream biomanufacturing applications...

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Mizoribine

Mizoribine is an imidazole nucleoside which acts as an immunosuppressant by inhibiting lymphocyte proliferation. Mizoribine is freely soluble in water (20 mg/mL).Mechanism of ActionMizoribine inhibits inosine monophosphate synthetase and guanosine...

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Monactin

Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore...

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