Circumdatin A, produced by Aspergillus sp., was first reported in 1999 by Rahbaek and colleagues, University of Copenhagen, Denmark. The structure of circumdatin A was revised as a unique oxepine in...
Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp. Beauveriolide III inhibits acyl-CoA:cholesterol acyltransferase (ACAT) to block the synthesis of cholesteryl ester,...
Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp.. Beauveriolides I and III inhibit macrophage acyl-CoA:cholesterol acyltransferase (ACAT) activity to block the synthesis...
Aminopterin is a 4-amino derivative of folic acid and a folic acid antagonist. It is a synthetic derivative of pterin. It has both mmunosuppressive properties and anti-cancer properties and can be...
Alternariol is a mycotoxin produced by Alternaria and is often found as a contaminant in fruit and small grain cereal products. Structurally, it is characterized as a dibenzopyranone. It can be...
Acetomycin, a γ-butyrolactone isolated from Streptomyces ramulosus, was first reported in 1958 by Ettlinger et al. at ETH Zurich. Acetomycin is potently active in vitro against HCT-8 human colon...
17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG, alvespimycin) is a semi-synthetic derivative of the benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus in which the...
Sulfasalazine is a synthetic salicylic acid derivative and sulfonamide which can act as an antirhematic and gastrointestinal agent. It is formulated as a prodrug, and is metabolized into active...
Hydrastine, EvoPure is a soquinoline alkaloid and an inhibitor of dopamine biosynthesis. It was discovered in 1851 by Alfred P Durand. It is a natural product from Hydrastis canadensis (goldenseal)...
Delafloxacin Meglumine is the meglumine salt of Delafloxacin. It is a small molecule and broad-spectrum fourth-generation fluoroquinolone antibiotic. It was developed by Melinta Therapeutics. It is...
Cefiderocol is a siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. It has in vitro activity against the non-fermenting Gram-negative bacteria causing urinary...
Baloxavir Marboxil is a synthetic antiviral compound. It has activity against viruses causing influenza A and influenza B. It originated by Shionogi (Japan). It is a small molecule inhibitor of...
