Clarithromycin related compound L, EvoPure® (6-O-Methylerythromycin A (Z)-9-oxime) is a highly purified impurity found in Clarithromycin that can be used as a reference standard.
We also offer:
- Clarithromycin related compound C, EvoPure® (C128)
- Clarithromycin related compound D, EvoPure® (C140)
- Clarithromycin related compound H, EvoPure® (C143)
- Clarithromycin related compound I, EvoPure® (C131)
- Clarithromycin related compound J, EvoPure® (C132)
- Clarithromycin related compound K, EvoPure® (C133)
- Clarithromycin related compound M, EvoPure® (C133)
- Clarithromycin related compound Z, EvoPure® (E022)
CAS Number: 127253-05-8
Molecular Formula: C38H70N2O13
Molecular Weight: 762.97
Mechanism of Action: Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to Clarithromycin is commonly attributed to mutations in 50S rRNA preventing Clarithromycin binding allowing the cell to synthesize error-free proteins.
Anti-cancer mechanisms include reduction of cytokines, inhibition of autophagy, and anti-angiogenesis. The compound can act on signal transduction pathways, transcription factors, drug pharmacokinetics, growth signals, and metastasis. These features can be exploited to make tumor cells more prone to apoptosis and reduce escape mechanisms. The mechanism used depend on the type of cancer.
Storage Conditions: -20°C
Tariff Code: 2941.90.5000