Ribostamycin is an aminoglycoside antibiotic and is freely soluble in aqueous solution at 88.7 mg/mL.
Ribostamycin is an aminoglycoside-aminocyclitol antibiotic isolated from Streptomyces ribosidificus, originally from a soil sample in Japan. It is an mportant broad-spectrum antibiotic with important use against human immunodeficiency virus. Resistance to aminoglycosides is a growing concern.
|Mechanism of Action||Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.|
|Microbiology Applications||Resistance is due to bacterial enzymes that modify the structure through phosphorylation, adenylation, and acetylation and prevent the antibiotic from being able to interact with the bacterial rRNAs.|
|Spectrum||Ribostamycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria.|
|Molecular Formula||C17H34N4O10 · H2SO4|
Davis BD (1987) Mechanism of bactericidal action of Aminoglycosides. Microbiol. Rev. 51.3:341-50.
|MIC||Borrelia burgdorferi S.L.| 8 － 64|| Escherichia coli| 8 － 12.5|||