SKU: R001  / 
    CAS Number: 53123-88-9


    $204.69 - $256.21

    Rapamycin (sirolimus) is a macrolide immunosuppressive and anti-tumor drug. Rapamycin is essentially insoluble in water.

    Chen et al. used rapamycin from TOKU-E to study the mammalian target of rapamycin. "AMPA receptor–mTOR activation is required for the antidepressant-like effects of sarcosine during the forced swim test in rats: insertion of AMPA receptor may play a role"

    Mechanism of ActionRapamycin complexes with FK-binding protein (FKBP12) and inhibits mTOR (FRAP, RAFT), a member of the phosphoinositide kinase-related kinase (PIKK) family.
    Cancer ApplicationsRapamycin suppresses the immune system by preventing T-cell and B-cells from responding to IL-2, a cytokine that would otherwise induce cell proliferation. These properties are especially useful post-transplant to reduce the likelihood of graft rejection. Rapamycin has also demonstrated anti-tumor properties by inducing cellular apoptosis and inhibiting cell division.
    SolubilityChloroform: 5 mg/mL
    Ethanol: Soluble
    Methanol: 25 mg/mL
    Water: Insoluble

    Law, B. K., and Et Al. "Rapamycin: An Anti-cancer Immunosuppressant?" Critical Reviews in Oncology and Hematology 56.1 (2005): 47-60. Oct. 2005. Web. 30 Aug. 2012.

    Dumont, F. J., and Su Q. "Mechanism of Action of the Immunosuppressant Rapamycin." Life Sciences 58.5 (1996): 373-95. Web. 30 Aug. 2012.