Quinomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumor agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumor progression and metastasis.
Quinomycin A is soluble in DMF and DMSO and has limited solubility in ethanol and methanol.
Quinomycin A is soluble in DMF and DMSO and has limited solubility in ethanol and methanol.
| Molecular Formula | C51H64N12O12S2 |
| References | Serendipitous SAD phasing of an echinomycin-(ACGTACGT)2 bisintercalation complex. Cuesta-Seijo J.A. et al. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 417. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Kong D. et al. Cancer Res. 2005, 65, 9047. Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. Park J.Y. et al. Pharmacol Res. 2004, 50, 201. |
