SKU: Q013  / 
    CAS Number: 111974-72-2

    Quetiapine Fumarate


    Quetiapine Fumarate is an inhibitor of dopamine and serotonin. Serotonin is a neurotransmitter thought to play a role in depression and schizophrenia.

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    Mechanism of ActionQuetiapine Fumarate is a dibenzothiazepine with antagonist activity at dopamine (D1, D2, D3) and serotonin (5-HT1A and 5-HT2) receptors. It also antagonizes adrenoreceptors (alpha 1A, alpha 1b, alpha 2) and histamine receptor (H1).
    Eukaryotic Cell Culture ApplicationsQuetiapine was found to alleviate oxidative stress in PC12 cells, leading to higher cell viability and a lower rate of apoptosis. These studies give new insight into the link between oxidative stress and pathophysiology of schizophrenia and Alzheimer's (Wang et al, 2005).
    Molecular FormulaC21H25N3O2S · 0.5C4H4O4
    SolubilitySlightly soluble in DMSO and DMF. slightly soluble in water.
    ReferencesRichelson E and Souder T (2000) Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci.68(1):29-39 PMID 11132243 Wetzel H et al (1995) Seroquel (ICI 204 636), a putative "atypical" antipsychotic, in szhizophrenia with positive symptomatology: Results of an open clinical trial and changes of neuroendocrinological and EEG parameters. Phychopharmacol 119(2):231-238 PMID 7659771 Wang H et al (2005) Olanzapine and quetiapine protect PC12 cells from B-amyloid peptide25-35-induced oxidative stress and the ensuring apoptosis. J. Neurosci. Res. 81(4):572-580