• Thiostrepton packaged and labeled.

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SKU: T007

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Description

Thiostrepton is a large cylic synthetic peptide antibiotic commonly used in topical antibiotic ointments. Thiostrepton is poorly soluble in water but soluble in DMSO and CHCl3. Thiostrepton (T007) meets USP specifications.

TOKU-E offers two forms of thiostrepton: thiostrepton (T007) and thiostrepton ultrapure (T042).

    CAS Number

    1393-48-2

    Molecular Formula

    C72H85N19O18S5

    Molecular Weight

    1664.89

    Mechanism of Action

    Thiostrepton blocks translation by interfering with elongation factors (EF) involved in ribosomal GTPase activity.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1050

    Spectrum

    Thiostrepton is a broad spectrum antibiotic which targets a wide range of gram positive and gram negative bacteria

Applications

    Cancer Applications

    Thiostrepton has demonstrated anti breast cancer properties by down regulating FOXM1, a key transcription factor in the cell division cycle.

Specifications

    Form

    Powder

    Appearance

    Off white powder

    Source

    Streptomyces azureus

    Melting Point

    246-256°C

    Assay

    (On Dried Basis): ≥900u/mg

    Loss on Drying

    ≤5.0%

    Residue On Ignition

    ≤1.0%

References

    References

    Marson, C. M., and J. M. Kwok. "Thiostrepton Selectively Targets Breast Cancer Cells through Inhibition of Forkhead Box M1 Expression." Molecular Cancer Therapeutics (2008): 2022-032. www.ncbi.gov. Web. 27 Aug. 2012.

    Walter, Justin D., Margaret Hunter, and Melanie Cobb. "Thiostrepton Inhibits Stable 70S Ribosome Binding and Ribosome-dependent GTPase Activation of Elongation Factor G and Elongation Factor 4." Oxford Journals (2011): n. pag. Nucleic Acids Research. Web. 27 Aug. 2012.

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