• Spiramycin packaged and labeled.

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SKU: S007

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Description

Spiramycin is a broad spectrum macrolide antibiotic and is slightly soluble in aqueous solution.

    CAS Number

    8025-81-8

    Molecular Formula

    Spiramycin I: C43H74N2O14

    Molecular Weight

    Spiramycin I: 843.05

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to spiramycin is commonly attributed to mutations in 50S rRNA preventing spiramycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Spiramycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria. In addition, spiramycin has demonstrated activity against toxoplasma parasites.

Applications

    Microbiology Applications

    Spiramycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gramnegative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Staphylococcus spp. 0.031 µg/mL – 0.063 µg/mL
    • For a complete list of spiramycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or Yellowish Powder

    Source

    Streptomyces Ambofaciens

    Elemental Analysis

    Composition:
    Spiramycin I: ≥80.0%
    Spiramycin II: ≤5.0%
    Spiramycin III: ≤10.0%
    Sum of Spiramycin I,II,III: ≥90.0%

    Impurity Profile

    Any Impurity: ≤2.0%
    Sulphated Ash: ≤0.1%

    pH

    8.5-10.5

    Optical Rotation

    -80.0° to -85.0°

    Assay

    (On Dried Basis): ≥4100 IU/mg

    Loss on Drying

    ≤3.5%

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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