• Piperacillin sodium packaged and labeled.

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SKU: P010

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Description

Piperacillin Sodium is the sodium salt form of Piperacillin, a semi-synthetic, extended spectrum fungistatic β-lactam fourth-generation ureidopenicillin.  Derived from Ampicillin, Piperacillin was developed by Toyama Chemical Co, Tokyo, Japan.  It can also be used to study multidrug resistance.  Piperacillin is freely soluble in aqueous solution.

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  • Piperacillin (P017)

    CAS Number

    59703-84-3

    Molecular Formula

    C23H26N5NaO7S

    Molecular Weight

    539.54

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 C

    Tariff Code

    2941.10.5000

    Spectrum

    Piperacillin is a broad-spectrum antibiotic targeting a wide range of susceptible Gram-positive and Gram-negative bacteria.  It targets both aerobic and anaerobic bacteria.  It can be used against Enterococcus species, Pseudomonas aeruginosa, and E. coli.

Applications

    Microbiology Applications

    Piperacillin is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC ranges include:

    • Neisseria spp. 0.015 µg/mL – 32 µg/mL
    • Bacteroides fragilis 0.25 µg/mL - 32 µg/mL

    For a representative e list of Piperacillin MIC values, click here.

    Plant Biology Applications

    In vitro antibacterial activity of Piperacillin against Agrobacterium tumefaciens strains LBA4404 and EHA101 was examined and found to be effective in eliminating the bacteria involved in Agrobacterium-mediated plant genetic transformation (Ogawa and Mii, 2004).

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Source

    semi-synthetic

    Impurity Profile

    Chromatographic Impurities:
    Piperacillin Related Compound A: ≤ 3.5%
    Piperacillin Related Compound C: ≤ 1.0%

    Water Content (Karl Fischer)

    ≤ 1.0%

    pH

    5.5 to 7.5

    Assay

    (Anhydrous Basis): 863 to 1007 µg/mg

References

    References

    Ida K, Hirata S, Nakamuta S and Koike M (1978) Inhibition of cell division of Escherichia coli by a new synthetic penicillin, Piperacillin. Antimicrob. Agents. Chemother. 14 (2) 257-266

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am. J. Med. 103:51

    Karlowsky J et al (2003)  Comparison of four antimicrobial susceptibility testing methods to determine the in vitro activities of Piperacillin and Piperacillin-Tazobactam against clinical isolates of Enterobacteriaceae and Pseudomonas aeruginosa. J. Clin. Microbiol  41(7):3339-3343

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