• Piperacillin packaged and labeled.

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SKU: P017

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Description

Piperacillin is an extended spectrum β-lactam antibiotic and resistant to many β-lactamases.

TOKU-E offers two forms of piperacillin: piperacillin (P017) and piperacillin sodium (P010). Piperacillin is sparingly soluble in aqueous solution at 0.119 mg/mL. Piperacillin sodium is freely soluble in aqueous solution.

    CAS Number

    61477-96-1

    Molecular Formula

    C23H27N5O7S

    Molecular Weight

    517.55

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.10.5000

    Spectrum

    Piperacillin is a broad spectrum antibiotic targeting a wide range of susceptible gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Piperacillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Neisseria spp. 0.015 µg/mL – 32 µg/mL
    • Bacteroides fragilis 0.25 µg/mL - 32 µg/mL
    • For a complete list of piperacillin MIC values, click here.

    Plant Biology Applications

    Piperacillin has been used in Agrobacterium mediated plant genetic modification as an Agrobacterium growth inhibitor specifically in strains LBA4404 and EHA101 (2004).

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Semi-synthetic

    Impurity Profile

    Related Substances:
    Impurity A: ≤ 1.0%
    Impurity B: ≤ 0.2%
    Impurity C: ≤ 0.4%
    Impurity D: ≤ 2.0%
    Ampicillin: ≤ 0.2%

    Water Content (Karl Fisher)

    2.0-4.0%

    pH

    2.0-4.5

    Optical Rotation

    +155° to +175°

    Assay

    (on dried basis): 96.0-103.0%

    Heavy Metals

    ≤ 0.002%

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Ogawa Y. and Mii M., Screening for highly active Ë-lactam antibiotics against Agrobacterium tumefaciens. Arch Microbiol, Vol. 181, pp. 331-336, 2004.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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