• Ofloxacin packaged and labeled.

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SKU: O001

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Description

Ofloxacin is a freely soluble (28.3 mg/mL) second generation fluoroquinolone antibiotic.

    CAS Number

    82419-36-1

    Molecular Formula

    C18H20FN3O4

    Molecular Weight

    361.37

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    2-8°C

    Tariff Code

    2934.99.3000

    Spectrum

    Ofloxacin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative organisms.

Applications

    Microbiology Applications

    Ofloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.016 µg/mL – 0.063 µg/mL
    • Escherichia coli 0.063 µg/mL – 0.125 µg/mL
    • For a complete list of ofloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| (RS)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (FPA) ; Ofloxacin Difluoro Carboxylic Acid|82419-35-0|C13H9F2NO4|281.21| Impurity B| (RS)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H-pyrido-[1,2,3-de]-1,4-benzoxazin-7-one|||| Impurity E| (RS)-9-Fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid; N-Desmethyl Ofloxacin HCl|82419-52-1|C17H18FN3O4|347.34| Impurity F| 4-[(RS)-6-Carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-10-yl]-1-methylpiperazine 1-Oxide Hydrochloride (Ofloxacin N-Oxide Acetate Salt)|104721-52-0|C20H24FN3O7|437.42| | Ofloxacin R-Isomer; (+)-(R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ;(R)-(+)-Ofloxacin ;D-Ofloxacin ; Levofloxacin R-Isome|100986-86-5|C18H20FN3O4|361.37|

    Melting Point

    250-257°C

    Optical Rotation

    -1° to +1°

    Assay

    (On Dried Basis): 98.5-101.5%

    Loss on Drying

    ≤0.2%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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