• Netilmicin sulfate packaged and labeled.

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SKU: N004

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Description

Netilmicin sulfate is an aminoglycoside antibiotic with a similar mechanism to gentamicin. Netilmicin is highly soluble in aqueous solution at >50 mg/mL.

    CAS Number

    56391-57-2

    Molecular Formula

    C21H41N5O7 •2.5 H2SO4

    Molecular Weight

    720.78

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1010

    Spectrum

    Netilmicin sulfate is a broad spectrum antibiotic commonly used against bacteria responsible for respiratory tract infections and skin infections.

Applications

    Microbiology Applications

    Netilmicin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa 0.5 µg/mL - 1 µg/mL
    • Staphylococcus aureus 0.008 µg/mL - 4 µg/mL
    • For a complete list of netilmicin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Source

    Semi-synthetic

    pH

    3.5-5.5

    Optical Rotation

    +88° to +96°

    Assay

    (On Dried Basis): ≥595 μg/mg

    Loss on Drying

    ≤15.0%

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

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