• Mupirocin packaged and labeled.

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SKU: M022

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Description

Mupirocin is a carboxylic acid bacteriostatic/bactericidal antibiotic.

TOKU-E offers three forms of mupirocin: mupirocin (M022), mupirocin lithium salt (M023), and mupirocin calcium . Mupirocin is sparingly soluble in aqueous solution at 26.5 µg/mL. Mupirocin lithium is freely soluble at 10 mg/mL.

    CAS Number

    12650-69-0

    Molecular Formula

    C26H44O9

    Molecular Weight

    500.62

    Mechanism of Action

    Mupirocin inhibits protein synthesis by binding to isoleucyl-tRNA synthetase, an enzyme which conjugates the amino acid isoleucine to its corresponding tRNA.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

    Spectrum

    Mupirocin is commonly used to target gram positive bacteria especially Methicillin resistant Staphylococcus aureus (MRSA).

Applications

    Microbiology Applications

    Mupirocin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive Staphylococcus microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Methicillin resistant Staphylococcus aureus 0.25 µg/mL – 0.39 µg/mL
    • For a complete list of mupirocin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Almost white or off-white powder

    Source

    Pseudomonas Fluorescens.

    Water Content (Karl Fisher)

    ≤ 1.0%

    pH

    3.5-4.5

    Optical Rotation

    -17° to -21°

    Assay

    (On Dried Basis): 920 – 1020 μg/mg

References

    References

    Hatfield, S. M., J. J. Leyden, and M. I. Parenti. "Mupirocin: A Topical Antibiotic with a Unique Structure and Mechanism of Action." PubMed (1987): 761-70. Http://www.ncbi.nlm.nih.gov. Web. 5 Aug. 2012.

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