• Marbofloxacin packaged and labeled.

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SKU: M014

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Description

Marbofloxacin is a third generation fluoroquinolone antibiotic and is freely soluble in aqueous solution.

    CAS Number

    115550-35-1

    Molecular Formula

    C17H19FN4O4

    Molecular Weight

    362.36

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.59.3600

    Spectrum

    Marbofloxacin is a broad spectrum antibiotic commonly used to target Pseudomonas and Staphylococci species.

Applications

    Microbiology Applications

    Marbofloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa 0.5 µg/mL
    • Staphylococcus aureus 0.25 µg/mL
    • For a complete list of marbofloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Light yellow crystalline powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| 6,7-difluoro-8-hydroxy-1-(methylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity B| 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic acid|||| Impurity C| 6,8-difluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity D| 6-fluoro-8-hydroxy-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity E| 8-ethoxy-6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity F| 4-[6-carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazin-10-yl]-1-methylpiperazine 1-oxide||||

    Melting Point

    268-269°C

    Assay

    (On Dried Basis): 99.0-101.0%

    Loss on Drying

    ≤0.5%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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