• Marbofloxacin packaged and labeled.

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SKU: M014

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Description

Marbofloxacin is broad-spectrum, third-generation fluoroquinolone antibiotic and is freely soluble in aqueous solution.  It is commonly used in studying antimicrobial resistance and antimicrobial susceptibility testing.

    CAS Number

    115550-35-1

    Molecular Formula

    C17H19FN4O4

    Molecular Weight

    362.36

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. DNA gyrase is required during DNA replication, thus causes an inhibition of DNA synthesis and cell division..

    Storage Conditions

    2-8°C

    Tariff Code

    2933.59.3600

    Spectrum

    Marbofloxacin is a broad-spectrum antibiotic active against Gram-positive and Gram-negative bacteiria including Pseudomonas and Staphylococci species. It is also active against Mycoplasma.

Applications

    Microbiology Applications

    Marbofloxacin is commonly used for in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. 
    Representative MIC values include:

    • Pseudomonas aeruginosa 0.5 µg/mL
    • Staphylococcus aureus 0.25 µg/mL

    For a representative list of Marbofloxacin MIC values, click here.

    The in vitro activity of Marbofloxacin, a quinolone, was evaluated on 124 anaerobic human strains isolated from the gut and  testing revealed that Marbofloxacin was similalr or superior to Ofloxacin for the whole anaerobes such as Enterococcus, Enterobacteriaceae, and Lactobacillus  (Dubreuil  et al, 1996). 



Specifications

    Form

    Powder

    Appearance

    Light yellow crystalline powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| 6,7-difluoro-8-hydroxy-1-(methylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity B| 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic acid|||| Impurity C| 6,8-difluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity D| 6-fluoro-8-hydroxy-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity E| 8-ethoxy-6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity F| 4-[6-carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazin-10-yl]-1-methylpiperazine 1-oxide||||

    Melting Point

    268-269°C

    Assay

    (On Dried Basis): 99.0-101.0%

    Loss on Drying

    ≤0.5%

References

    References

    Dubreuil L, Houcke I and Leroy I (1996)  In vitro activity of a new fluoroquinolone, marbofloxacin (RO 09-1168) against strictly anaerobic bacteria and some bacteria from human fecal flora.   Pathol-biol. 44(5):333-336  PMID 8758470

    Spring M, Deleforge J, Thomas V, Boisrme B and Drugeon H (1995)  Antibacterial activity of marbofloxacin. A new fluoroquinolone for veterinary use against canine and feline isolates. J. Vet. Pharmacol and Ther. 18(4):284-289  PMID 8583541

    Wolfson, JS and David C. Hooper DC (1985)  The Fluoroquinolones: Structures, mechanisms of action and resistance, and spectra of activity in vitro  Antimicrob. Agents. Chemother. 28: 581-586  PMID  3000292

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