• Lovastatin (Mevinolin) packaged and labeled.

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SKU: L013

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Description

Lovastatin is a statin prodrug commonly used to combat hypercholesterolemia. Lovastatin inhibits HMG-CoA reductase, a significant enzyme involved in the cholesterol synthesis pathway. Lovastatin is insoluble in aqueous solution.

    CAS Number

    75330-75-5

    Molecular Formula

    C24H36O5

    Molecular Weight

    404.54

    Mechanism of Action

    Lovastatin is an inhibitor of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate

    Storage Conditions

    2-8°C

    Tariff Code

    2932.20.5050

Applications

    Cancer Applications

    Research has shown that statin drugs including lovastatin have been able to inhibit melanoma cell growth when high concentrations are used.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Monascus Ruber

    Optical Rotation

    +234° to +338°

    Assay

    98.5-101.0%

    Loss on Drying

    ≤0.3%

References

    References

    Eustace, A. J., and et al. "The 3-hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors, Simvastatin, Lovastatin and Mevastatin Inhibit Proliferation and Invasion of Melanoma Cells." BMC Cancer 8.9 (2008): www.ncbi.gov. 16 Jan. 2008. Web. 31 Aug. 2012.

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