• Levofloxacin packaged and labeled.

click on thumbnail to zoom
SKU: L001

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Levofloxacin is a synthetic fluoroquinolone antibiotic similar to ofloxacin.  Levofloxacin is insoluble in aqueous solution.

    CAS Number

    138199-71-0

    Molecular Formula

    C18H20FN3O4 • 0.5H2O

    Molecular Weight

    370.38

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.59.3600

    Spectrum

    Levofloxacin is a broad spectrum antibiotic targeting bacteria responsible for pneumonia including Streptococcus pneumoniae, and Haemophilus influenzae.

Applications

    Microbiology Applications

    Levofloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.00625 µg/mL – 1 µg/mL
    • Streptococcus pneumoniae 0.05 µg/mL - 4 µg/mL
    • For a complete list of levofloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Light Yellow Crystalline Powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; N-Desmethyl Levofloxacin|117707-40-1|C17H18FN3O4|347.34| Impurity B| 8,9-Difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid; Levofloxacin Difluoro Carboxylic Acid|100986-89-8|C13H9F2NO4|281.21| Impurity C| Ethyl (S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate ; Levofloxacin Ethyl Ester|177472-30-9|C20H24FN3O4|389.42| Impurity D||||| Impurity UN1| LEVOFLOXACIN N-OXIDE ; (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid N-oxide||C18H20FN3O5|377.37| Levofloxacin R-Isomer| (+)-(R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (R)-(+)-Ofloxacin; D-Ofloxacin; D-Levofloxacin|100986-86-5|C18H20FN3O4|361.37| Levofloxacin Desethylene Impurity| N,N*-Desethylene Levofloxacin Hydrochloride; (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-[(2-methylamino)ethylamino]-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine||C16H19ClFN3O4|371.79| Levofloxacin Descarboxy Impurity| (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine|178964-53-9|C17H20FN3O2|317.36| Levofloxacin Desethylene Diformyl Impurity| Desethylene Diformyl Levofloxacin; N,N*-Desethylene-N,N*-diformyl Levofloxacin; (S)-9-Fluoro-10-[formyl[2-(formylmethylamino)ethyl]amino]-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid|151377-74-1|C18H18FN3O6|391.35| Levofloxacin Desfluoro Impurity| (-)-(S)-2,3-Dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid|117620-85-6|C18H21N3O4|343.38|

    Melting Point

    218-227 °C

    Optical Rotation

    -95° to -103°

    Assay

    ≥98.5%

    Loss on Drying

    ≤3.0%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

Other Items In This Category