• Gentamicin A sulfate, EvoPure packaged and labeled.

click on thumbnail to zoom
SKU: G035

  Click 'Bulk Order' for 10 or more
Price: make selection(s)

Gentamicin A is one of several different components found in standard grade gentamicin. Gentamicin A, gentamicin B, gentamicin X2, and others are considered “minor components,” have little antimicrobial activity, and account for approximately 20% of standard grade gentamicin. The major components of gentamicin are members of the gentamicin C complex which account for up to 80% of standard grade gentamicin and possess higher antimicrobial properties. The minor gentamicin components (A, B, X2, etc..) contain hydroxy groups in the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) ring. The gentamicin C complex does not have hydroxy groups at these locations. This structural difference is thought to account for the difference in antimicrobial activity between the minor (gentamicins A, B, X2, etc..) and the gentamicin C complex. Gentamicin A sulfate, EvoPure® is ≥99.0% gentamicin A.

For more gentamicin products, click here.

Huang et al. used gentamicin A sulfate, EvoPure® and gentamicin X2 sulfate, EvoPure® to study enzymatic conversion of gentamicin A2 to other gentamicin congeners. "Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex."

    CAS Number


    Molecular Formula

    C18H36N4O10 · xH2SO4 (lot specific)

    Molecular Weight

    468.50 g/mol (Free base)

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions


    Tariff Code



    Gentamicin is a broad spectrum antibiotic targeting a wide range of Gram positive and Gram negative bacteria. Interestingly, gentamicin has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."


    Microbiology Applications

    Gentamicin EvoPure® compounds can be used to study effects of individual gentamicin components on various bacterial strains.





    White powder


    Micromonospora spp.

Technical Data

Spectral Data - Gentamicin A, EvoPure®

HNMR Spectra


Click to enlarge

Solvent: cdc13
Instrument: Mercury 300
Frequency: 300 MHz


FTIR Spectra

Click to enlarge


Mass Spectra

Click to enlarge

Polarity/Scan Type: Positive
Solvent: H2O
Solution Concentration: 10 mg/mL


    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

    Sarna, Katarzyna, and Agata Blazewicz. "Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection." PubMed (2010)

    Vydrin, A. F. "Component Composition of Gentamicin Sulfate Preparations." Pharmaceutical Chemistry Journal 37.8 (2003): 448-49. Web. 15 Oct. 2013.

Other Items In This Category