• Gatifloxacin packaged and labeled.

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SKU: G004

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Description

Gatifloxacin is a fourth generation fluoroquinolone antibiotic and is freely soluble in pH 4 at 60 mg/mL.

    CAS Number

    180200-66-2

    Molecular Formula

    C19H22FN3O4 • 1.5H2O

    Molecular Weight

    375.39 g/mol

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Storage Conditions

    2-8 °C

    Tariff Code

    2933.59.3600

    Spectrum

    Gatifloxacin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria especially those which cause pneumonia and skin infections.

Applications

    Microbiology Applications

    Gatifloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Staphylococcus aureus 0.25 µg/mL - 4 µg/mL
    • Streptococcus pneumoniae 0.5 µg/mL - 4 µg/mL
    • For a complete list of gatifloxacin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Whitish or yellowish crystalline powder

    Source

    Synthetic

    Impurity Profile

    Impurity A| 1-Cyclopropyl-6-fluoro-8-hydroxy-7-(3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; O-Desmethyl Gatifloxaci|616205-76-6|C18H20FN3O4|361.37| Impurity B| 1-Cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; Difluoro Hydroxy Gatifloxacin|154093-72-8|C13H9F2NO4|281.21| Impurity C| 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; Difluoro Methoxy Gatifloxacin||C14H11F2NO4|295.24| Impurity D| 1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; 3-Desmethyl Gatifloxacin|112811-57-1|C18H20FN3O4|361.37| Impurity E| 1-Cyclopropyl-6-fluoro-8-methoxy-7-(2-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Gatifloxacin 2-Methyl Isomer|1029364-65-5|C19H22FN3O4|375.39|

    Melting Point

    182-185 °C

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

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