• FK506 packaged and labeled.

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SKU: F001

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Description

FK506, also known as Tacrolimus, is a macrolide immunosuppressive drug commonly used post-transplant to reduce graft rejection. Tacrolimus is insoluble in aqueous solution.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    CAS Number

    109581-93-3

    Molecular Formula

    C44H69NO12

    Molecular Weight

    804.02

    Mechanism of Action

    Tacrolimus forms complexes with other immune proteins which inhibit IL-2 cytokine production which ultimately suppresses T-cell proliferation and cytotoxicity.

    Storage Conditions

    -20°C

    Tariff Code

    2934.99.4700

Applications

    Eukaryotic Cell Culture Applications

    Tacrolimus can be used in mammalian cell culture to study the effects of T-cell mediated cytotoxicity.

Specifications

    Form

    Powder

    Appearance

    White powder

    Melting Point

    871.7°C

    Loss on Drying

    ≤3.0%

References

    References

    Thomson, A. W., and C. A. Bonham. "Mode of Action of Tacrolimus (FK506): Molecular and Cellular Mechanisms." Therapeutic Drug Monitoring 17.6 (1995): 584-91.www.ncbi.gov. Pittsburgh Transplantation Institute, Dec. 1995. Web. 31 Aug. 2012.

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