• Erythromycin Estolate packaged and labeled.

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SKU: E003

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Description

Erythromycin estolate is a macrolide antibiotic with a target spectrum similar to penicillin.

TOKU-E offers three forms of erythromycin: erythromycin (E002), erythromycin estolate (E003), and erythromycin ethylsuccinate (E004).  Erythromycin is sparingly soluble in aqueous solution (2 mg/mL).  Erythromycin estolate and erythromycin ethylsuccinate are both freely soluble in organic solvents.
 

    CAS Number

    3521-62-8

    Molecular Formula

    C40H71NO14 · C12H26SO4

    Molecular Weight

    1056.39 g/mol

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to erythromycin is commonly attributed to mutations in 50S rRNA preventing erythromycin binding allowing the cell to synthesize proteins free of error.

    Tariff Code

    2941.50.0000

    Spectrum

    Erythromycin is a broad spectrum antibiotic commonly targeting bacteria responsible for respiratory tract infections including Mycoplasma pneumoniae and Legionella pneumophila

Applications

    Microbiology Applications

    Erythromycin estolate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and Mycoplasma species.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Mycoplasma pneumoniae 0.0019 µg/mL – 0.0078 µg/mL
    • Legionella pneumophila 0.008 µg/mL – 1 µg/mL
    • For a  complete list of erythromycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Actinomycete saccha

    Water Content (Karl Fisher)

    <4.0%

    Melting Point

    132-138 °C

    Assay

    Not less than 610 u/mg (dried basis)

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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